Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 397 | 43790.3 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 2 | A | Serine/threonine-protein kinase B-raf | polymer | 283 | 32098.1 | 1 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 3 | B, A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | B, A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | B | N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide | non-polymer | 431.2 | 1 | Chemie (QOA) |
Sequence modifications
B: 1 - 393 (UniProt: Q02750)
A: 445 - 723 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Ala 218 | Ser 218 | engineered mutation |
| Ala 222 | Ser 222 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | - | expression tag |
| Gly 442 | - | expression tag |
| Gly 443 | - | expression tag |
| Arg 444 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75888.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1492.2 | |
| All* | Total formula weight | 77380.6 |
