7M0R

Cryo-EM structure of the Sema3A/PlexinA4/Neuropilin 1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E, F	Neuropilin-1	polymer	567	64132.2	2	UniProt (P97333) Pfam (PF00431) Pfam (PF00754) In PDB	Mus musculus (Mouse)	A5 protein
2	C, D	Semaphorin-3A	polymer	614	67931.8	2	UniProt (O08665) Pfam (PF01403) In PDB	Mus musculus (Mouse)	Semaphorin III,Sema III,Semaphorin-D,Sema D
3	A, B	Plexin-A4	polymer	1194	133253.2	2	UniProt (Q80UG2) Pfam (PF01403) Pfam (PF01833) Pfam (PF01437) Pfam (PF17960) Pfam (PF18020) In PDB	Mus musculus (Mouse)
4	E, F	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)

Sequence modifications

C, D: 21 - 569 (UniProt: O08665)

PDB	External Database	Details
Lys 106	Ala 106	engineered mutation
Val 475	Ile 475	conflict
Ala 551	Arg 551	engineered mutation
Ala 555	Arg 555	engineered mutation

C, D: 592 - 676 (PDB: 7M0R)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	530634.5
Non-Polymers*	Number of molecules	4
	Total formula weight	160.3
All*	Total formula weight	530794.8

*Water molecules are not included.