7M0R
Cryo-EM structure of the Sema3A/PlexinA4/Neuropilin 1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (E, F) | Neuropilin-1 | polymer | 567 | 64132.2 | 2 | UniProt (P97333) Pfam (PF00431) Pfam (PF00754) | Mus musculus (Mouse) | A5 protein |
| 2 | B, D (C, D) | Semaphorin-3A | polymer | 614 | 67931.8 | 2 | UniProt (O08665) Pfam (PF01403) | Mus musculus (Mouse) | Semaphorin III,Sema III,Semaphorin-D,Sema D |
| 3 | E, F (A, B) | Plexin-A4 | polymer | 1194 | 133253.2 | 2 | UniProt (Q80UG2) Pfam (PF01403) Pfam (PF01833) Pfam (PF01437) Pfam (PF17960) Pfam (PF18020) | Mus musculus (Mouse) | |
| 4 | G, H, I, J (E, F) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence modifications
C, D: 21 - 569 (UniProt: O08665)
C, D: 592 - 676 (PDB: 7M0R)
| PDB | External Database | Details |
|---|---|---|
| Lys 106 | Ala 106 | engineered mutation |
| Val 475 | Ile 475 | conflict |
| Ala 551 | Arg 551 | engineered mutation |
| Ala 555 | Arg 555 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 530634.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 160.3 | |
| All* | Total formula weight | 530794.8 |
