7LZR
Crystal structure of the BCL6 BTB domain in complex with OICR-10256
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | B-cell lymphoma 6 protein | polymer | 125 | 14415.7 | 4 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | E, K, N, S, T (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | F, I, O (A, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | G, L, M, Q, U (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | H, J, P, R (A, B, C, D) | N-[5-chloro-2-(morpholin-4-yl)pyridin-4-yl]-2-[5-(3-cyano-4-hydroxy-5-methylphenyl)-3-methyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]acetamide | non-polymer | 534.0 | 4 | Chemie (YJJ) | |||
| 6 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 319 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57662.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3069.7 | |
| All* | Total formula weight | 60732.5 |
