7LZR

Crystal structure of the BCL6 BTB domain in complex with OICR-10256

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG26
A	SER27
A	ASP29
A	ARG44
D	ASP29
D	ARG44

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 202

Chain	Residue
A	THR92
A	HOH301
D	SER27
D	ARG28
A	ASN23
A	ARG26
A	ASP88

---

site_id	AC3
Number of Residues	1
Details	binding site for residue CL A 203

Chain	Residue
A	ASN73

---

site_id	AC4
Number of Residues	24
Details	binding site for residue YJJ A 204

Chain	Residue
A	MET51
A	ALA52
A	CYS53
A	SER54
A	GLY55
A	TYR58
A	PHE89
A	GLN113
A	MET114
A	GLU115
A	HIS116
A	VAL117
A	HOH315
A	HOH324
B	HIS14
B	ASP17
B	ASN21
B	ARG24
B	LEU25
B	ARG28
C	GLU81
C	ILE85
C	ASN96
C	ARG98

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 205

Chain	Residue
A	LEU31
A	ASP33
A	LYS47
A	THR48
B	ASP33
B	LYS47
B	THR48

---

site_id	AC6
Number of Residues	21
Details	binding site for residue YJJ B 201

Chain	Residue
A	HIS14
A	ASP17
A	ARG24
A	LEU25
A	ARG28
B	MET51
B	ALA52
B	CYS53
B	SER54
B	GLY55
B	TYR58
B	PHE89
B	GLN113
B	MET114
B	GLU115
B	HIS116
B	VAL117
B	HOH319
B	HOH329
B	HOH337
D	HOH372

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 B 202

Chain	Residue
A	ASP75
A	ILE78
A	HOH344
B	ASP75
B	GLU77
B	ILE78
B	HOH322

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL B 203

Chain	Residue
B	ARG98
B	GLU99
B	GLY100

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CL B 204

Chain	Residue
B	THR12

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 C 201

Chain	Residue
C	PHE11
C	THR12
C	ARG13
D	HIS116

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL C 202

Chain	Residue
C	ASP33
C	LYS47
C	THR48
D	ASP33
D	LYS47
D	THR48

---

site_id	AD3
Number of Residues	20
Details	binding site for residue YJJ C 203

Chain	Residue
C	VAL117
C	HOH323
C	HOH331
C	HOH340
D	HIS14
D	ASP17
D	ARG24
D	LEU25
A	ASN96
C	MET51
C	ALA52
C	CYS53
C	SER54
C	GLY55
C	TYR58
C	PHE89
C	GLN113
C	MET114
C	GLU115
C	HIS116

---

site_id	AD4
Number of Residues	2
Details	binding site for residue CL C 204

Chain	Residue
C	ARG67
D	LEU31

---

site_id	AD5
Number of Residues	26
Details	binding site for residue YJJ D 201

Chain	Residue
B	GLU41
B	PHE43
B	GLU81
B	HOH303
C	HIS14
C	ASP17
C	ASN21
C	ARG24
C	LEU25
C	ARG28
D	MET51
D	ALA52
D	CYS53
D	SER54
D	GLY55
D	TYR58
D	PHE89
D	GLN113
D	MET114
D	GLU115
D	HIS116
D	VAL117
D	HOH314
D	HOH328
D	HOH337
D	HOH345

---

site_id	AD6
Number of Residues	7
Details	binding site for residue SO4 D 202

Chain	Residue
C	HIS116
C	HOH319
D	GLN10
D	PHE11
D	THR12
D	ARG13
D	HOH316

---

site_id	AD7
Number of Residues	6
Details	binding site for residue SO4 D 203

Chain	Residue
D	THR32
D	ASP33
D	VAL34
D	VAL35
D	ARG44
D	SER70

---

site_id	AD8
Number of Residues	1
Details	binding site for residue CL D 204

Chain	Residue
D	LYS66

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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