7LZ5
Crystal structure of oncogenic KRAS Q61E GMPPCP-bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Isoform 2B of GTPase KRas | polymer | 169 | 19256.7 | 1 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) In PDB | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | A | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | non-polymer | 521.2 | 1 | Chemie (GCP) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 1 - 164 (UniProt: P01116-2)
PDB | External Database | Details |
---|---|---|
Glu 61 | Gln 61 | engineered mutation |
Ser 118 | Cys 118 | engineered mutation |
Lys 165 | - | expression tag |
His 166 | - | expression tag |
Lys 167 | - | expression tag |
Glu 168 | - | expression tag |
Lys 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 19256.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 545.5 | |
All* | Total formula weight | 19802.2 |