7LZ5
Crystal structure of oncogenic KRAS Q61E GMPPCP-bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 169 | 19256.7 | 1 | UniProt (P01116-2) Pfam (PF00071) UniProt (by SIFTS) (P01116) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B (A) | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | non-polymer | 521.2 | 1 | Chemie (GCP) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (A) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 1 - 164 (UniProt: P01116-2)
| PDB | External Database | Details |
|---|---|---|
| Glu 61 | Gln 61 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Lys 165 | - | expression tag |
| His 166 | - | expression tag |
| Lys 167 | - | expression tag |
| Glu 168 | - | expression tag |
| Lys 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19256.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 545.5 | |
| All* | Total formula weight | 19802.2 |
