7LYX
Crystal structure of human CYP8B1 in complex with (S)-tioconazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase | polymer | 489 | 57129.7 | 1 | UniProt (Q9UNU6) Pfam (PF00067) | Homo sapiens (Human) | 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase,CYPVIIIB1,Cytochrome P450 8B1,Sterol 12-alpha-hydroxylase |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | (S)-Tioconazole | non-polymer | 387.7 | 1 | Chemie (YHM) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 6 | F (A) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 26 - 501 (UniProt: Q9UNU6)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | initiating methionine |
| Ala 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Lys 22 | - | expression tag |
| Thr 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Ser 25 | - | expression tag |
| His 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 57129.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1135.4 | |
| All* | Total formula weight | 58265.1 |
