7LTT

SAMHD1(113-626) H206R D207N R366C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	535	61852.7	4	UniProt (Q9Y3Z3) Pfam (PF01966) In PDB	Homo sapiens (Human)	dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1
2	A, B, C, D	2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (DGT)
3	A, B, C	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4		water	water		18.0	611	Chemie (HOH)

Sequence modifications

A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)

PDB	External Database	Details
Met 92	-	initiating methionine
Gly 93	-	expression tag
Ser 94	-	expression tag
Ser 95	-	expression tag
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
Ser 102	-	expression tag
Ser 103	-	expression tag
Gly 104	-	expression tag
Leu 105	-	expression tag
Val 106	-	expression tag
Pro 107	-	expression tag
Arg 108	-	expression tag
Gly 109	-	expression tag
Ser 110	-	expression tag
His 111	-	expression tag
Met 112	-	expression tag
Arg 206	His 206	engineered mutation
Asn 207	Asp 207	engineered mutation
Cys 366	Arg 366	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	247410.8
Non-Polymers*	Number of molecules	12
	Total formula weight	4154.7
All*	Total formula weight	251565.4

*Water molecules are not included.