7LPY

Crystal structures and ribonuclease activity of the Flavivirus host factor ERI3 that is involved in viral RNA synthesis define the ERI subfamily of structure-specific 3-prime - 5-prime exoribonucleases

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ERI1 exoribonuclease 3	polymer	216	25068.1	2	UniProt (O43414) Pfam (PF00929) In PDB	Homo sapiens (Human)	Prion interactor 1,Prion protein-interacting protein
2	A, B	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
3	A, B	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	158	Chemie (HOH)

Sequence modifications

A, B: 137 - 337 (UniProt: O43414)

PDB	External Database	Details
Met 122	-	initiating methionine
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
Glu 129	-	expression tag
Asn 130	-	expression tag
Leu 131	-	expression tag
Tyr 132	-	expression tag
Phe 133	-	expression tag
Gln 134	-	expression tag
Ser 135	-	expression tag
Met 136	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50136.1
Non-Polymers*	Number of molecules	7
	Total formula weight	1006.3
All*	Total formula weight	51142.4

*Water molecules are not included.