7LMS

Structure of human SetD3 methyl-transferase in complex with 2A protease from Coxsackievirus B3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Protease 2A	polymer	151	16584.5	1	UniProt (P03313)	Coxsackievirus B3 (strain Nancy)
2	B (A)	Actin-histidine N-methyltransferase	polymer	596	67483.1	1	UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273)	Homo sapiens (Human)	SET domain-containing protein 3,hSETD3
3	C (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (13792) PubChem (177678424) PubChem (189149) PubChem (439155) PubChem (25210495) PubChem (21125603) PubChem (44361184) PubChem (25203782) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (52224400) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (5284331) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (71170554) PubChem (13231890) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (164157219) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)

Sequence modifications

B: 1 - 147 (UniProt: P03313)

PDB	External Database	Details
Ser -3	-	expression tag
Asn -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Ala 107	Cys 961	engineered mutation

A: 2 - 594 (UniProt: Q86TU7)

PDB	External Database	Details
Ser -1	-	expression tag
Asn 0	-	expression tag
Ala 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84067.6
Non-Polymers*	Number of molecules	2
	Total formula weight	449.8
All*	Total formula weight	84517.4

*Water molecules are not included.