7LMS
Structure of human SetD3 methyl-transferase in complex with 2A protease from Coxsackievirus B3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Protease 2A | polymer | 151 | 16584.5 | 1 | UniProt (P03313) Pfam (PF00947) | Coxsackievirus B3 (strain Nancy) | |
| 2 | B (A) | Actin-histidine N-methyltransferase | polymer | 596 | 67483.1 | 1 | UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273) | Homo sapiens (Human) | SET domain-containing protein 3,hSETD3 |
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) |
Sequence modifications
B: 1 - 147 (UniProt: P03313)
A: 2 - 594 (UniProt: Q86TU7)
| PDB | External Database | Details |
|---|---|---|
| Ser -3 | - | expression tag |
| Asn -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 107 | Cys 961 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84067.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 449.8 | |
| All* | Total formula weight | 84517.4 |
