7LMS

Structure of human SetD3 methyl-transferase in complex with 2A protease from Coxsackievirus B3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Protease 2A	polymer	151	16584.5	1	UniProt (P03313) Pfam (PF00947) In PDB	Coxsackievirus B3 (strain Nancy)
2	A	Actin-histidine N-methyltransferase	polymer	596	67483.1	1	UniProt (Q86TU7) Pfam (PF00856) Pfam (PF09273) In PDB	Homo sapiens (Human)	SET domain-containing protein 3,hSETD3
3	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)

Sequence modifications

B: 1 - 147 (UniProt: P03313)

PDB	External Database	Details
Ser -3	-	expression tag
Asn -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag
Ala 107	Cys 961	engineered mutation

A: 2 - 594 (UniProt: Q86TU7)

PDB	External Database	Details
Ser -1	-	expression tag
Asn 0	-	expression tag
Ala 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84067.6
Non-Polymers*	Number of molecules	2
	Total formula weight	449.8
All*	Total formula weight	84517.4

*Water molecules are not included.