7LL5
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 293 | 34498.4 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | B (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | C (A) | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile | non-polymer | 559.7 | 1 | Chemie (Y5G) | |||
| 4 | D (A) | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34498.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 621.8 | |
| All* | Total formula weight | 35120.1 |
