7LIW
Local refinement of human ATP citrate lyase E599Q mutant ASH domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | ATP-citrate synthase | polymer | 1101 | 120983.1 | 4 | UniProt (P53396) Pfam (PF16114) Pfam (PF02629) Pfam (PF00549) Pfam (PF00285) In PDB | Homo sapiens (Human) | ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme |
| 2 | B | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 3 | B | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) | |||
| 4 | B | (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid | non-polymer | 272.1 | 1 | Chemie (Y2A) |
Sequence modifications
A, B, C, D: 1 - 1101 (UniProt: P53396)
| PDB | External Database | Details |
|---|---|---|
| Gln 599 | Glu 599 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 483932.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1466.8 | |
| All* | Total formula weight | 485399.4 |
