7LGK
Crystal structure of soluble guanylate cyclase activator runcaciguat (BAY 1101042) bound to nostoc H-NOX domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | H-NOX domain protein | polymer | 182 | 20358.8 | 2 | UniProt (Q8YUQ7) Pfam (PF07700) In PDB | Nostoc sp. PCC 7120 = FACHB-418 | |
| 2 | A, B | Runcaciguat | non-polymer | 488.3 | 2 | Chemie (XZ7) | |||
| 3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | A, B | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 182 (UniProt: Q8YUQ7)
| PDB | External Database | Details |
|---|---|---|
| Ala 139 | Cys 139 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40717.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1600.1 | |
| All* | Total formula weight | 42317.7 |
