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7LG6

BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, G, M
(A, E, F)
Envelope glycoprotein gp120polymer47553268.43UniProt (Q2N0S6)
Pfam (PF00516)
Human immunodeficiency virus 1BG505 SOSIP.v5.2 gp120
2B, H, N
(H, O, P)
VRC40.01 Fab Heavy Chainpolymer23124800.23Homo sapiens
3C, I, O
(L, Q, R)
VRC40.01 Fab Kappa Light Chainpolymer21423616.33Homo sapiens
4D, J, P
(B, G, I)
Envelope glycoprotein gp41polymer15317178.53UniProt (Q2N0S6)
Pfam (PF00517)
Human immunodeficiency virus 1 (HIV-1)BG505 SOSIP.v5.2 gp41
5E, K, Q
(D, M, N)
RM19R Fab Kappa Light Chainpolymer21423568.23Macaca mulatta
6F, L, R
(C, J, K)
RM19R Fab Heavy Chainpolymer22523979.73Macaca mulatta
7AA, AB, BA, BB, CA...
(a, 0, b, 1, c...)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.430In PDB
GlyTouCan (G42666HT)
8HA, T, VA
(h, T, v)
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.53In PDB
GlyTouCan (G15407YE)
9KA, W, YA
(k, W, y)
alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.03In PDB
GlyTouCan (G56014GC)
10LA, X, ZA
(l, X, z)
alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1397.23In PDB
GlyTouCan (G80966KZ)
11FA, HB, TA
(f, 7, t)
alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched367.33In PDB
GlyTouCan (G86851RC)
12IB, JB, KB, LB, MB...
(A, B, E, G, F...)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.218Chemie (NAG)
Sequence modifications
A, E, F: 31 - 507 (UniProt: Q2N0S6)
PDBExternal DatabaseDetails
Lys 64Glu 63engineered mutation
Cys 73Ala 72engineered mutation
Trp 316Ala 313engineered mutation
Asn 332Thr 330engineered mutation
Cys 501Ala 498engineered mutation
B, G, I: 512 - 664 (UniProt: Q2N0S6)
PDBExternal DatabaseDetails
Pro 559Ile 556engineered mutation
Cys 561Ala 558engineered mutation
Cys 605Thr 602engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains18
Total formula weight499233.7
BranchedNumber of molecules42
Total formula weight23004.3
Non-Polymers*Number of molecules18
Total formula weight3981.7
All*Total formula weight526219.8
*Water molecules are not included.

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PDB entries from 2024-11-06

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