7LG6
BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M (A, E, F) | Envelope glycoprotein gp120 | polymer | 475 | 53268.4 | 3 | UniProt (Q2N0S6) Pfam (PF00516) | Human immunodeficiency virus 1 | BG505 SOSIP.v5.2 gp120 |
| 2 | B, H, N (H, O, P) | VRC40.01 Fab Heavy Chain | polymer | 231 | 24800.2 | 3 | Homo sapiens | ||
| 3 | C, I, O (L, Q, R) | VRC40.01 Fab Kappa Light Chain | polymer | 214 | 23616.3 | 3 | Homo sapiens | ||
| 4 | D, J, P (B, G, I) | Envelope glycoprotein gp41 | polymer | 153 | 17178.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 (HIV-1) | BG505 SOSIP.v5.2 gp41 |
| 5 | E, K, Q (D, M, N) | RM19R Fab Kappa Light Chain | polymer | 214 | 23568.2 | 3 | Macaca mulatta | ||
| 6 | F, L, R (C, J, K) | RM19R Fab Heavy Chain | polymer | 225 | 23979.7 | 3 | Macaca mulatta | ||
| 7 | AA, AB, BA, BB, CA... (a, 0, b, 1, c...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 30 | In PDB GlyTouCan (G42666HT) | |||
| 8 | HA, T, VA (h, T, v) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 9 | KA, W, YA (k, W, y) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G56014GC) | |||
| 10 | LA, X, ZA (l, X, z) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 3 | In PDB GlyTouCan (G80966KZ) | |||
| 11 | FA, HB, TA (f, 7, t) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 3 | In PDB GlyTouCan (G86851RC) | |||
| 12 | IB, JB, KB, LB, MB... (A, B, E, G, F...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
A, E, F: 31 - 507 (UniProt: Q2N0S6)
B, G, I: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Lys 64 | Glu 63 | engineered mutation |
| Cys 73 | Ala 72 | engineered mutation |
| Trp 316 | Ala 313 | engineered mutation |
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | engineered mutation |
| Cys 561 | Ala 558 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 499233.7 | |
| Branched | Number of molecules | 42 |
| Total formula weight | 23004.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 526219.8 |
