7LFX

Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	cGMP-gated cation channel alpha-1	polymer	560	64650.4	4	UniProt (P29973) Pfam (PF00520) Pfam (PF00027) Pfam (PF16526)	Homo sapiens (Human)	Cyclic nucleotide-gated cation channel 1,Cyclic nucleotide-gated channel alpha-1,CNG1,Cyclic nucleotide-gated channel,photoreceptor,Rod photoreceptor cGMP-gated channel subunit alpha
2	E, H, I, J (A, B, C, D)	CYCLIC GUANOSINE MONOPHOSPHATE	non-polymer		345.2	4	Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904)
3	F, G (A)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)

Sequence modifications

A, B, C, D: 144 - 690 (UniProt: P29973)

PDB	External Database	Details
Met 131	-	initiating methionine
Asp 132	-	expression tag
Tyr 133	-	expression tag
Lys 134	-	expression tag
Asp 135	-	expression tag
Asp 136	-	expression tag
Asp 137	-	expression tag
Asp 138	-	expression tag
Lys 139	-	expression tag
Gly 140	-	expression tag
Gly 141	-	expression tag
Ser 142	-	expression tag
Ala 143	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	258601.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1461.0
All*	Total formula weight	260062.7

*Water molecules are not included.