7LBE
CryoEM structure of the HCMV Trimer gHgLgO in complex with neutralizing fabs 13H11 and MSL-109
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Envelope glycoprotein H | polymer | 767 | 87311.3 | 1 | UniProt (Q6SW67) Pfam (PF02489) Pfam (PF17488) | Human cytomegalovirus (strain Merlin) (HHV-5) | gH |
| 2 | B (B) | Envelope glycoprotein L | polymer | 278 | 30846.5 | 1 | UniProt (F5HCH8) Pfam (PF01801) | Human cytomegalovirus (strain Merlin) (HHV-5) | gL |
| 3 | C (C) | Envelope glycoprotein O | polymer | 504 | 58298.5 | 1 | UniProt (Q8BCU3) Pfam (PF07982) | Human cytomegalovirus (HHV-5) | UL74,UL74 protein |
| 4 | D (E) | Fab 13H11 light chain | polymer | 237 | 25780.0 | 1 | Homo sapiens | ||
| 5 | E (F) | Fab 13H11 heavy chain | polymer | 250 | 26600.1 | 1 | Homo sapiens | ||
| 6 | F (G) | Fab MSL-109 light chain | polymer | 257 | 28355.8 | 1 | Homo sapiens | ||
| 7 | G (H) | Fab MSL-109 heavy chain | polymer | 257 | 27547.8 | 1 | Homo sapiens | ||
| 8 | H (D) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 9 | I, J (I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 10 | AA, K, L, M, N... (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 16 | Chemie (NAG) | |||
| 11 | Y (C) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) |
Sequence modifications
A: 1 - 715 (UniProt: Q6SW67)
C: 1 - 464 (UniProt: Q8BCU3)
| PDB | External Database | Details |
|---|---|---|
| Gly 716 | - | expression tag |
| Thr 717 | - | expression tag |
| Lys 718 | - | expression tag |
| Leu 719 | - | expression tag |
| Gly 720 | - | expression tag |
| Pro 721 | - | expression tag |
| Glu 722 | - | expression tag |
| Gln 723 | - | expression tag |
| Lys 724 | - | expression tag |
| Leu 725 | - | expression tag |
| Ile 726 | - | expression tag |
| Ser 727 | - | expression tag |
| Glu 728 | - | expression tag |
| Glu 729 | - | expression tag |
| Asp 730 | - | expression tag |
| Leu 731 | - | expression tag |
| Asn 732 | - | expression tag |
| Ser 733 | - | expression tag |
| Ala 734 | - | expression tag |
| Val 735 | - | expression tag |
| Asp 736 | - | expression tag |
| Gly 737 | - | expression tag |
| Ser 738 | - | expression tag |
| Gly 739 | - | expression tag |
| Leu 740 | - | expression tag |
| Asn 741 | - | expression tag |
| Asp 742 | - | expression tag |
| Ile 743 | - | expression tag |
| Phe 744 | - | expression tag |
| Glu 745 | - | expression tag |
| Ala 746 | - | expression tag |
| Gln 747 | - | expression tag |
| Lys 748 | - | expression tag |
| Ile 749 | - | expression tag |
| Glu 750 | - | expression tag |
| Trp 751 | - | expression tag |
| His 752 | - | expression tag |
| Glu 753 | - | expression tag |
| Asn 754 | - | expression tag |
| Leu 755 | - | expression tag |
| Tyr 756 | - | expression tag |
| Phe 757 | - | expression tag |
| Gln 758 | - | expression tag |
| Gly 759 | - | expression tag |
| His 760 | - | expression tag |
| His 761 | - | expression tag |
| His 762 | - | expression tag |
| His 763 | - | expression tag |
| His 764 | - | expression tag |
| His 765 | - | expression tag |
| His 766 | - | expression tag |
| His 767 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 465 | - | expression tag |
| Ser 466 | - | expression tag |
| Glu 467 | - | expression tag |
| Asn 468 | - | expression tag |
| Leu 469 | - | expression tag |
| Tyr 470 | - | expression tag |
| Phe 471 | - | expression tag |
| Gln 472 | - | expression tag |
| Gly 473 | - | expression tag |
| Ser 474 | - | expression tag |
| Ala 475 | - | expression tag |
| Trp 476 | - | expression tag |
| Ser 477 | - | expression tag |
| His 478 | - | expression tag |
| Pro 479 | - | expression tag |
| Gln 480 | - | expression tag |
| Phe 481 | - | expression tag |
| Glu 482 | - | expression tag |
| Lys 483 | - | expression tag |
| Gly 484 | - | expression tag |
| Gly 485 | - | expression tag |
| Gly 486 | - | expression tag |
| Ser 487 | - | expression tag |
| Gly 488 | - | expression tag |
| Gly 489 | - | expression tag |
| Gly 490 | - | expression tag |
| Ser 491 | - | expression tag |
| Gly 492 | - | expression tag |
| Gly 493 | - | expression tag |
| Gly 494 | - | expression tag |
| Ser 495 | - | expression tag |
| Ala 496 | - | expression tag |
| Trp 497 | - | expression tag |
| Ser 498 | - | expression tag |
| His 499 | - | expression tag |
| Pro 500 | - | expression tag |
| Gln 501 | - | expression tag |
| Phe 502 | - | expression tag |
| Glu 503 | - | expression tag |
| Lys 504 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 284740.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1921.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3719.5 | |
| All* | Total formula weight | 290381.3 |
