7LAZ
Crystal structure of the first bromodomain (BD1) of human BRD3 bound to ERK5-IN-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Bromodomain-containing protein 3 | polymer | 123 | 14586.8 | 2 | UniProt (Q15059) Pfam (PF00439) In PDB | Homo sapiens (Human) | RING3-like protein |
| 2 | A, B | 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 638.8 | 2 | Chemie (VYJ) | |||
| 3 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A, B: 24 - 144 (UniProt: Q15059)
| PDB | External Database | Details |
|---|---|---|
| Ser 22 | - | expression tag |
| Met 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29173.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1277.6 | |
| All* | Total formula weight | 30451.3 |
