7LAZ
Crystal structure of the first bromodomain (BD1) of human BRD3 bound to ERK5-IN-1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue VYJ A 201 |
| Chain | Residue |
| A | TRP57 |
| A | PRO58 |
| A | PHE59 |
| A | ASN116 |
| A | HOH304 |
| B | ASN69 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue VYJ B 201 |
| Chain | Residue |
| A | LYS78 |
| B | TRP57 |
| B | PRO58 |
| B | GLN61 |
| B | LEU68 |
| B | ASN116 |
| B | ILE122 |
| B | HOH303 |
| B | HOH306 |
| A | HIS53 |
| A | GLN54 |
| A | PHE55 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFyqpvDaiklnlpDYHkiIknpMdmgtIkkrlenny..Ywsasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA56-TYR115 |
