7LAF
15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Polyunsaturated fatty acid lipoxygenase ALOX15B | polymer | 689 | 77374.9 | 2 | UniProt (O15296) Pfam (PF01477) Pfam (PF00305) In PDB | Homo sapiens (Human) | 15-lipoxygenase 2,15-LOX-2,Arachidonate 15-lipoxygenase B,15-LOX-B,Arachidonate 15-lipoxygenase type II,Linoleate 13-lipoxygenase 15-LOb |
2 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
3 | A, B | 3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole | non-polymer | 281.4 | 2 | Chemie (XRP) | |||
4 | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 676 (UniProt: O15296)
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
- | Pro 73 | deletion |
- | Pro 74 | deletion |
- | Val 75 | deletion |
- | Leu 76 | deletion |
- | Pro 77 | deletion |
- | Leu 78 | deletion |
- | Leu 79 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 154749.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 672.6 | |
All* | Total formula weight | 155422.5 |