7LAF

15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Polyunsaturated fatty acid lipoxygenase ALOX15B	polymer	689	77374.9	2	UniProt (O15296) Pfam (PF01477) Pfam (PF00305)	Homo sapiens (Human)	15-lipoxygenase 2,15-LOX-2,Arachidonate 15-lipoxygenase B,15-LOX-B,Arachidonate 15-lipoxygenase type II,Linoleate 13-lipoxygenase 15-LOb
2	C, F (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	D, E (A, B)	3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole	non-polymer		281.4	2	Chemie (XRP)
4	G, H (A, B)	water	water		18.0	365	Chemie (HOH)

Sequence modifications

A, B: 1 - 676 (UniProt: O15296)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
-	Pro 73	deletion
-	Pro 74	deletion
-	Val 75	deletion
-	Leu 76	deletion
-	Pro 77	deletion
-	Leu 78	deletion
-	Leu 79	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	154749.8
Non-Polymers*	Number of molecules	4
	Total formula weight	672.6
All*	Total formula weight	155422.5

*Water molecules are not included.