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7LAF

15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001676biological_processlong-chain fatty acid metabolic process
A0005506molecular_functioniron ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0005925cellular_componentfocal adhesion
A0006629biological_processlipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006690biological_processicosanoid metabolic process
A0006915biological_processapoptotic process
A0008285biological_processnegative regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0016020cellular_componentmembrane
A0016165molecular_functionlinoleate 13S-lipoxygenase activity
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0019369biological_processarachidonic acid metabolic process
A0019372biological_processlipoxygenase pathway
A0030336biological_processnegative regulation of cell migration
A0030850biological_processprostate gland development
A0030856biological_processregulation of epithelial cell differentiation
A0032722biological_processpositive regulation of chemokine production
A0034440biological_processlipid oxidation
A0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
A0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
A0043651biological_processlinoleic acid metabolic process
A0045618biological_processpositive regulation of keratinocyte differentiation
A0045786biological_processnegative regulation of cell cycle
A0045926biological_processnegative regulation of growth
A0046872molecular_functionmetal ion binding
A0050473molecular_functionarachidonate 15-lipoxygenase activity
A0051122biological_processhepoxilin biosynthetic process
A0051213molecular_functiondioxygenase activity
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0071926biological_processendocannabinoid signaling pathway
A1901696biological_processcannabinoid biosynthetic process
A1990136molecular_functionlinoleate 9S-lipoxygenase activity
A2001303biological_processlipoxin A4 biosynthetic process
B0001676biological_processlong-chain fatty acid metabolic process
B0005506molecular_functioniron ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0005925cellular_componentfocal adhesion
B0006629biological_processlipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006690biological_processicosanoid metabolic process
B0006915biological_processapoptotic process
B0008285biological_processnegative regulation of cell population proliferation
B0008289molecular_functionlipid binding
B0010744biological_processpositive regulation of macrophage derived foam cell differentiation
B0016020cellular_componentmembrane
B0016165molecular_functionlinoleate 13S-lipoxygenase activity
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0019369biological_processarachidonic acid metabolic process
B0019372biological_processlipoxygenase pathway
B0030336biological_processnegative regulation of cell migration
B0030850biological_processprostate gland development
B0030856biological_processregulation of epithelial cell differentiation
B0032722biological_processpositive regulation of chemokine production
B0034440biological_processlipid oxidation
B0035360biological_processpositive regulation of peroxisome proliferator activated receptor signaling pathway
B0036403molecular_functionarachidonate 8(S)-lipoxygenase activity
B0043651biological_processlinoleic acid metabolic process
B0045618biological_processpositive regulation of keratinocyte differentiation
B0045786biological_processnegative regulation of cell cycle
B0045926biological_processnegative regulation of growth
B0046872molecular_functionmetal ion binding
B0050473molecular_functionarachidonate 15-lipoxygenase activity
B0051122biological_processhepoxilin biosynthetic process
B0051213molecular_functiondioxygenase activity
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0071926biological_processendocannabinoid signaling pathway
B1901696biological_processcannabinoid biosynthetic process
B1990136molecular_functionlinoleate 9S-lipoxygenase activity
B2001303biological_processlipoxin A4 biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00081
Number of Residues11
DetailsLIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. CHPLfKLLiPH
ChainResidueDetails
ACYS395-HIS405

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCSAKH
ChainResidueDetails
APHE547-HIS553

site_idPS00711
Number of Residues15
DetailsLIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEaltHlLHSHLLpE
ChainResidueDetails
AHIS368-GLU382

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:24497644
ChainResidueDetails
AGLY15
BGLY17
BASP39
BASN40
BGLY42
BGLU44
BPHE92
BGLN93
AGLY17
AASP39
AASN40
AGLY42
AGLU44
APHE92
AGLN93
BGLY15

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00726, ECO:0000269|PubMed:24497644
ChainResidueDetails
ALEU380
ATHR385
AGLN560
BLEU380
BTHR385
BGLN560

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PDB entries from 2024-07-24

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