7LA9
Crystal structure of the first bromodomain (BD1) of human BRD4 (BRD4-1) in complex with bivalent inhibitor NC-III-49-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Bromodomain-containing protein 4 | polymer | 125 | 14881.1 | 6 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | G, O, R (A, B, C) | N,N'-(oxybis{(ethane-2,1-diyl)oxyethane-2,1-diyloxy[3-(2-methyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-4,1-phenylene]})di(ethane-1-sulfonamide) | non-polymer | 875.0 | 3 | Chemie (XR7) | |||
| 3 | CA, EA, FA, H, I... (E, F, A, B, C...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 4 | AA, BA, DA, GA, M... (D, E, F, A, B...) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 5 | W (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | X (D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | HA, IA, JA, KA, LA... (A, B, C, D, E...) | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 89286.6 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3906.7 | |
| All* | Total formula weight | 93193.4 |
