7L9I
Crystal structure of human ARH3-D314A bound to magnesium and ADP-ribose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, D, A, B) | ADP-ribose glycohydrolase ARH3 | polymer | 366 | 39234.0 | 4 | UniProt (Q9NX46) Pfam (PF03747) | Homo sapiens (Human) | ADP-ribosylhydrolase 3,O-acetyl-ADP-ribose deacetylase ARH3,Poly(ADP-ribose) glycohydrolase ARH3,[Protein ADP-ribosylarginine] hydrolase-like protein 2,[Protein ADP-ribosylserine] hydrolase |
| 2 | E, G, I, K (C, D, A, B) | [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | non-polymer | 559.3 | 4 | Chemie (AR6) PubChem (192) PubChem (25113622) PubChem (25113623) PubChem (44415180) PubChem (51051599) PubChem (44144391) PubChem (445794) PubChem (447048) PubChem (89379870) PubChem (33576) PubChem (447165) PubChem (448826) PubChem (91746164) PubChem (9548001) PubChem (9547960) PubChem (122606931) PubChem (122609061) PubChem (10437766) PubChem (174159053) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949) | |||
| 3 | F, H, J, L (C, D, A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | M, N, O, P (C, D, A, B) | water | water | 18.0 | 839 | Chemie (HOH) |
Sequence modifications
C, D, A, B: 1 - 363 (UniProt: Q9NX46)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 314 | Asp 314 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 156935.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2334.5 | |
| All* | Total formula weight | 159270.3 |
