7L9H

Crystal structure of human ARH3-D77A bound to magnesium and ADP-ribose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (C, D, A, B)	ADP-ribose glycohydrolase ARH3	polymer	366	39233.9	4	UniProt (Q9NX46) Pfam (PF03747)	Homo sapiens (Human)	ADP-ribosylhydrolase 3,O-acetyl-ADP-ribose deacetylase ARH3,Poly(ADP-ribose) glycohydrolase ARH3,[Protein ADP-ribosylarginine] hydrolase-like protein 2,[Protein ADP-ribosylserine] hydrolase
2	E, G, I, K (C, D, A, B)	[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE	non-polymer		559.3	4	Chemie (AR6)
3	F, H, J, L (C, D, A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	M, N, O, P (C, D, A, B)	water	water		18.0	909	Chemie (HOH)

Sequence modifications

C, D, A, B: 1 - 363 (UniProt: Q9NX46)

PDB	External Database	Details
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag
Ala 77	Asp 77	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	156935.8
Non-Polymers*	Number of molecules	8
	Total formula weight	2334.5
All*	Total formula weight	159270.3

*Water molecules are not included.