7L9H

Crystal structure of human ARH3-D77A bound to magnesium and ADP-ribose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006974	biological_process	DNA damage response
A	0016604	cellular_component	nuclear body
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0060546	biological_process	negative regulation of necroptotic process
A	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
A	0071451	biological_process	cellular response to superoxide
A	0090734	cellular_component	site of DNA damage
A	0140290	biological_process	peptidyl-serine ADP-deribosylation
A	0140292	molecular_function	ADP-ribosylserine hydrolase activity
B	0000287	molecular_function	magnesium ion binding
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006281	biological_process	DNA repair
B	0006287	biological_process	base-excision repair, gap-filling
B	0006974	biological_process	DNA damage response
B	0016604	cellular_component	nuclear body
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0060546	biological_process	negative regulation of necroptotic process
B	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
B	0071451	biological_process	cellular response to superoxide
B	0090734	cellular_component	site of DNA damage
B	0140290	biological_process	peptidyl-serine ADP-deribosylation
B	0140292	molecular_function	ADP-ribosylserine hydrolase activity
C	0000287	molecular_function	magnesium ion binding
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006281	biological_process	DNA repair
C	0006287	biological_process	base-excision repair, gap-filling
C	0006974	biological_process	DNA damage response
C	0016604	cellular_component	nuclear body
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0060546	biological_process	negative regulation of necroptotic process
C	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
C	0071451	biological_process	cellular response to superoxide
C	0090734	cellular_component	site of DNA damage
C	0140290	biological_process	peptidyl-serine ADP-deribosylation
C	0140292	molecular_function	ADP-ribosylserine hydrolase activity
D	0000287	molecular_function	magnesium ion binding
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006281	biological_process	DNA repair
D	0006287	biological_process	base-excision repair, gap-filling
D	0006974	biological_process	DNA damage response
D	0016604	cellular_component	nuclear body
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0060546	biological_process	negative regulation of necroptotic process
D	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
D	0071451	biological_process	cellular response to superoxide
D	0090734	cellular_component	site of DNA damage
D	0140290	biological_process	peptidyl-serine ADP-deribosylation
D	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Glutamate flap","evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---