7L7G
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (B, A) | Translation initiation factor eIF-2B subunit epsilon | polymer | 721 | 80452.6 | 2 | UniProt (Q13144) Pfam (PF02020) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit epsilon |
| 2 | B, F (J, I) | Translation initiation factor eIF-2B subunit gamma | polymer | 452 | 50304.2 | 2 | UniProt (Q9NR50) Pfam (PF00483) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit gamma |
| 3 | C, G (C, D) | Translation initiation factor eIF-2B subunit beta | polymer | 368 | 41008.6 | 2 | UniProt (P49770) Pfam (PF01008) | Homo sapiens (Human) | S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta |
| 4 | D, H (F, E) | Translation initiation factor eIF-2B subunit delta | polymer | 523 | 57640.2 | 2 | UniProt (Q9UI10) Pfam (PF01008) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit delta |
| 5 | I, J (H, G) | Translation initiation factor eIF-2B subunit alpha | polymer | 305 | 33754.1 | 2 | UniProt (Q14232) Pfam (PF01008) | Homo sapiens (Human) | eIF-2B GDP-GTP exchange factor subunit alpha |
| 6 | K (D) | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide | non-polymer | 451.3 | 1 | Chemie (C7B) |
Sequence modifications
B, A: 1 - 721 (UniProt: Q13144)
C, D: 2 - 351 (UniProt: P49770)
| PDB | External Database | Details |
|---|---|---|
| Val 587 | Ile 587 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Tyr -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Gln 0 | - | expression tag |
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 526319.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 451.3 | |
| All* | Total formula weight | 526770.8 |
