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7L6R

Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1), S-Adenosyl-L-homocysteine (SAH) and Manganese (Mn).

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A2'-O-methyltransferasepolymer30033556.41UniProt (P0DTD1)
Pfam (PF06460)
In PDB
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)NSP16
2BNon-structural protein 10polymer14115004.11UniProt (P0DTD1)
Pfam (PF09401)
In PDB
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)NSP10
3CRNA (5'-D(*(M7G))-R(P*(A2M)P*UP*UP*AP*A)-3')polymer72338.41synthetic construct
4AMANGANESE (II) IONnon-polymer54.91Chemie (MN)
5ACHLORIDE IONnon-polymer35.52Chemie (CL)
6ASULFATE IONnon-polymer96.11Chemie (SO4)
7AS-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
8Aalpha-D-glucopyranosenon-polymer180.24Chemie (GLC)
9BZINC IONnon-polymer65.41Chemie (ZN)
10Bbeta-D-fructopyranosenon-polymer180.21Chemie (BDF)
11waterwater18.0341Chemie (HOH)
Sequence modifications
A: 6799 - 7096 (UniProt: P0DTD1)
PDBExternal DatabaseDetails
Ser 6797-expression tag
Asn 6798-expression tag
B: 4254 - 4392 (UniProt: P0DTD1)
PDBExternal DatabaseDetails
Ser 4252-expression tag
Asn 4253-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight50899.0
Non-Polymers*Number of molecules11
Total formula weight1572.5
All*Total formula weight52471.5
*Water molecules are not included.

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PDB entries from 2024-06-12

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