7L6R
Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1), S-Adenosyl-L-homocysteine (SAH) and Manganese (Mn).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2'-O-methyltransferase | polymer | 300 | 33556.4 | 1 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | NSP16 |
| 2 | B (B) | Non-structural protein 10 | polymer | 141 | 15004.1 | 1 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | NSP10 |
| 3 | C (C) | RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*UP*AP*A)-3') | polymer | 7 | 2338.4 | 1 | synthetic construct | ||
| 4 | D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 5 | E, F (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | G (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 7 | H (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 8 | I, J, K, L (A) | alpha-D-glucopyranose | non-polymer | 180.2 | 4 | Chemie (GLC) | |||
| 9 | M (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 10 | N (B) | beta-D-fructopyranose | non-polymer | 180.2 | 1 | Chemie (BDF) | |||
| 11 | O, P, Q (A, B, C) | water | water | 18.0 | 341 | Chemie (HOH) |
Sequence modifications
A: 6799 - 7096 (UniProt: P0DTD1)
B: 4254 - 4392 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 6797 | - | expression tag |
| Asn 6798 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 4252 | - | expression tag |
| Asn 4253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 50899.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1572.5 | |
| All* | Total formula weight | 52471.5 |
