7L2R
Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, E, F (A, B, C, D) | Transient receptor potential cation channel subfamily V member 1 | polymer | 637 | 73016.4 | 4 | UniProt (O35433) Pfam (PF00023) Pfam (PF00520) | Rattus norvegicus (Rat) | TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1,Vanilloid receptor type 1-like |
| 2 | B, C (F, E) | Tau-theraphotoxin-Hs1a | polymer | 76 | 8684.2 | 2 | UniProt (P0CH43) | Cyriopagopus schmidti (Chinese bird spider) | Tau-TRTX-Hs1a,Double-knot toxin,DkTx |
| 3 | G, K, M, N (A, B, C, D) | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate | non-polymer | 600.6 | 4 | Chemie (XJ7) | |||
| 4 | H, J, L, O (A, F, C, D) | (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate | non-polymer | 481.6 | 4 | Chemie (65I) | |||
| 5 | I (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 110 - 764 (UniProt: O35433)
F, E: 1 - 75 (UniProt: P0CH43)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| - | Asn 604 | deletion |
| - | Asn 605 | deletion |
| - | Ser 606 | deletion |
| - | Leu 607 | deletion |
| - | Pro 608 | deletion |
| - | Met 609 | deletion |
| - | Glu 610 | deletion |
| - | Ser 611 | deletion |
| - | Thr 612 | deletion |
| - | Pro 613 | deletion |
| - | His 614 | deletion |
| - | Lys 615 | deletion |
| - | Cys 616 | deletion |
| - | Arg 617 | deletion |
| - | Gly 618 | deletion |
| - | Ser 619 | deletion |
| - | Ala 620 | deletion |
| - | Cys 621 | deletion |
| - | Lys 622 | deletion |
| - | Pro 623 | deletion |
| - | Gly 624 | deletion |
| - | Asn 625 | deletion |
| - | Ser 626 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 309433.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 4351.8 | |
| All* | Total formula weight | 313785.5 |
