Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7L2R

Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0008289	molecular_function	lipid binding
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
E	0099106	molecular_function	ion channel regulator activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0008289	molecular_function	lipid binding
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	100
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	104
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	88
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"24305160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3J5P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IRZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IS0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	128
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	100
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	108
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	144
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	92
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	112
Details	Region: {"description":"AD","evidences":[{"source":"PubMed","id":"15190102","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	12
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"10931826","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PDB","id":"2PNN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PDB","id":"2NYJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PNN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IRX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NER1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9R186","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA and PKD","evidences":[{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15471852","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine; by PKA; in vitro","evidences":[{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC/PRKCE","evidences":[{"source":"PubMed","id":"11884385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12194871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"14630912","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	58
Details	Repeat: {"description":"Domain 1","evidences":[{"source":"PubMed","id":"20510930","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	58
Details	Repeat: {"description":"Domain 2","evidences":[{"source":"PubMed","id":"20510930","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	138
Details	Region: {"description":"2 X approximate repeats with cysteine pattern C-C-CC-C-C","evidences":[{"source":"PubMed","id":"20510930","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	8
Details	Site: {"description":"Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix)","evidences":[{"source":"PubMed","id":"27281200","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	2
Details	Site: {"description":"Important residue for activation of TRPV1","evidences":[{"source":"PubMed","id":"26880553","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	2
Details	Site: {"description":"Important residue for activation of TRPV1","evidences":[{"source":"PubMed","id":"26880553","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)