7L2R

Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0008289	molecular_function	lipid binding
E	0035821	biological_process	modulation of process of another organism
E	0090729	molecular_function	toxin activity
E	0099106	molecular_function	ion channel regulator activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0008289	molecular_function	lipid binding
F	0035821	biological_process	modulation of process of another organism
F	0090729	molecular_function	toxin activity
F	0099106	molecular_function	ion channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interacts with TRPV1 (reaches into the void formed by S4, S6 and pore-helix) => ECO:0000269|PubMed:27281200

Chain	Residue	Details
F	TRP11
B	GLU536-THR556
B	MET572-ILE599
B	LEU681-GLU709
C	ILE433-TYR453
C	TYR472-LEU497
C	TYR511-PHE531
C	GLU536-THR556
C	MET572-ILE599
C	LEU681-GLU709
D	ILE433-TYR453
F	PHE27
D	TYR472-LEU497
D	TYR511-PHE531
D	GLU536-THR556
D	MET572-ILE599
D	LEU681-GLU709
F	TRP53
F	PHE67
E	TRP11
E	PHE27
E	TRP53
E	PHE67
B	TYR511-PHE531

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Important residue for activation of TRPV1 => ECO:0000305|PubMed:26880553

Chain	Residue	Details
F	MET25
D	TYR454-ASP471
D	SER532-LYS535
D	GLU600-PHE649
E	MET25
A	GLU600-PHE649
B	TYR454-ASP471
B	SER532-LYS535
B	GLU600-PHE649
C	TYR454-ASP471
C	SER532-LYS535
C	GLU600-PHE649

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Important residue for activation of TRPV1 => ECO:0000269|PubMed:26880553

Chain	Residue	Details
F	LEU65
E	LEU65
B	GLN498-SER510
B	ARG557-LYS571
C	GLN498-SER510
C	ARG557-LYS571
D	GLN498-SER510
D	ARG557-LYS571

---

site_id	SWS_FT_FI4
Number of Residues	88
Details	INTRAMEM: Pore-forming => ECO:0000269|PubMed:24305160, ECO:0000269|PubMed:27281200, ECO:0000305|PubMed:10931826

Chain	Residue	Details
A	THR650-ILE672
B	THR650-ILE672
C	THR650-ILE672
D	THR650-ILE672

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744|PDB:2PNN

Chain	Residue	Details
A	ARG115
D	ARG115
D	LYS155
D	GLU210
A	LYS155
A	GLU210
B	ARG115
B	LYS155
B	GLU210
C	ARG115
C	LYS155
C	GLU210

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0007744|PDB:2NYJ, ECO:0007744|PDB:2PNN

Chain	Residue	Details
A	LYS160
D	LYS160
D	ASN164
D	TYR199
A	ASN164
A	TYR199
B	LYS160
B	ASN164
B	TYR199
C	LYS160
C	ASN164
C	TYR199

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:27281200, ECO:0007744|PDB:5IRX

Chain	Residue	Details
A	TYR511
D	TYR511
D	THR550
D	ARG557
A	THR550
A	ARG557
B	TYR511
B	THR550
B	ARG557
C	TYR511
C	THR550
C	ARG557

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9R186

Chain	Residue	Details
A	LEU669
B	LEU669
C	LEU669
D	LEU669

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKA and PKD => ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:15471852

Chain	Residue	Details
A	SER116
B	SER116
C	SER116
D	SER116

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphothreonine; by PKA; in vitro => ECO:0000269|PubMed:12194871

Chain	Residue	Details
A	THR144
A	THR370
B	THR144
B	THR370
C	THR144
C	THR370
D	THR144
D	THR370

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC/PRKCE => ECO:0000269|PubMed:11884385, ECO:0000269|PubMed:12194871, ECO:0000269|PubMed:14630912

Chain	Residue	Details
A	SER502
B	SER502
C	SER502
D	SER502

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14630912

Chain	Residue	Details
A	GLN727
B	GLN727
C	GLN727
D	GLN727

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11683872

Chain	Residue	Details
A	TYR627
B	TYR627
C	TYR627
D	TYR627

---