7L24
HPK1 IN COMPLEX WITH COMPOUND 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 288 | 32335.7 | 4 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (Human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEKKK 1 |
| 2 | E, F, G, H (A, B, C, D) | 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazolo[4,3-c]pyridine | non-polymer | 417.5 | 4 | Chemie (XHV) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 7 - 294 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Ala 171 | Ser 171 | engineered mutation |
| Cys 191 | Gly 191 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 129342.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1669.9 | |
| All* | Total formula weight | 131012.7 |
