7KZ0
Human MBD4 glycosylase domain bound to DNA containing substrate analog 2'-deoxy-pseudouridine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methyl-CpG-binding domain protein 4 | polymer | 174 | 20560.6 | 1 | UniProt (O95243) | Homo sapiens (Human) | Methyl-CpG-binding endonuclease 1,Methyl-CpG-binding protein MBD4,Mismatch-specific DNA N-glycosylase |
| 2 | B (C) | DNA (5'-D(*CP*CP*AP*GP*CP*GP*(P2U)P*GP*CP*AP*GP*C)-3') | polymer | 12 | 3634.4 | 1 | synthetic construct | ||
| 3 | C (D) | DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3') | polymer | 12 | 3695.4 | 1 | synthetic construct | ||
| 4 | D, F, G (A, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 6 | H, I, J (A, C, D) | water | water | 18.0 | 263 | Chemie (HOH) |
Sequence modifications
A: 426 - 580 (UniProt: O95243)
| PDB | External Database | Details |
|---|---|---|
| Met 407 | - | expression tag |
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Ser 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
| His 415 | - | expression tag |
| His 416 | - | expression tag |
| Ser 417 | - | expression tag |
| Ser 418 | - | expression tag |
| Gly 419 | - | expression tag |
| Leu 420 | - | expression tag |
| Val 421 | - | expression tag |
| Pro 422 | - | expression tag |
| Arg 423 | - | expression tag |
| Gly 424 | - | expression tag |
| Ser 425 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 27890.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 315.4 | |
| All* | Total formula weight | 28205.7 |
