7KXW

Crystal structure of DCLK1-KD in complex with DCLK1-IN-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase DCLK1	polymer	280	31379.7	1	UniProt (O15075) Pfam (PF00069) In PDB	Homo sapiens (Human)	Doublecortin domain-containing protein 3A,Doublecortin-like and CAM kinase-like 1,Doublecortin-like kinase 1
2	B	Serine/threonine-protein kinase DCLK1	polymer	280	31299.7	1	UniProt (O15075) Pfam (PF00069) In PDB	Homo sapiens (Human)	Doublecortin domain-containing protein 3A,Doublecortin-like and CAM kinase-like 1,Doublecortin-like kinase 1
3	A, B	2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5-(2,2,2-trifluoroethyl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one	non-polymer		527.5	2	Chemie (XBD)
4	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5	B	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
6		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A: 372 - 649 (UniProt: O15075)

PDB	External Database	Details
Gly 370	-	expression tag
Ser 371	-	expression tag

B: 372 - 649 (UniProt: O15075)

PDB	External Database	Details
Gly 370	-	expression tag
Ser 371	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62679.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1355.4
All*	Total formula weight	64034.9

*Water molecules are not included.