7KUY
Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glycine receptor subunit alpha-2 | polymer | 364 | 41676.0 | 4 | UniProt (P23416) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | |
2 | E | Glycine receptor subunit beta, Green fluorescent protein chimera | polymer | 702 | 78765.1 | 1 | UniProt (P48167) UniProt (P42212) Pfam (PF02931) Pfam (PF02932) Pfam (PF01353) In PDB | Homo sapiens (Human) | Glycine receptor 58 kDa subunit |
3 | A, B, C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
4 | A, B, C, D, E | STRYCHNINE | non-polymer | 334.4 | 5 | Chemie (SY9) |
Sequence modifications
A, B, C, D: 1 - 316 (UniProt: P23416)
A, B, C, D: 382 - 425 (UniProt: P23416)
E: 3 - 331 (UniProt: P48167)
E: 331 - 340 (UniProt: P42212)
E: 340 - 475 (UniProt: P48167)
A, B, C, D: 382 - 425 (UniProt: P23416)
PDB | External Database | Details |
---|---|---|
Gly 378 | - | linker |
Ser 379 | - | linker |
Ser 380 | - | linker |
Gly 381 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly -19 | - | expression tag |
Val -18 | - | expression tag |
Ala -17 | - | expression tag |
Met -16 | - | expression tag |
Pro -15 | - | expression tag |
Gly -14 | - | expression tag |
Ala -13 | - | expression tag |
Glu -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Val -9 | - | expression tag |
Val -8 | - | expression tag |
Ala -7 | - | expression tag |
Ala -6 | - | expression tag |
Leu -5 | - | expression tag |
Glu -4 | - | expression tag |
Val -3 | - | expression tag |
Leu -2 | - | expression tag |
Phe -1 | - | expression tag |
Gln 0 | - | expression tag |
Gly 1 | - | expression tag |
Pro 2 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 333 | Phe 64 | conflict |
Thr 333 | Ser 65 | conflict |
Lys 339 | Ala 206 | conflict |
Leu 340 | His 231 | conflict |
Ser 340 | - | linker |
Gly 340 | - | linker |
Ser 340 | - | linker |
Gly 340 | - | linker |
Ser 340 | - | linker |
Gly 340 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 331 | - | linker |
Gly 331 | - | linker |
Ser 331 | - | linker |
Ser 331 | - | linker |
Ala 331 | - | linker |
Ala 331 | - | linker |
Ala 331 | - | linker |
Val 331 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 245469.1 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 3662.9 | |
All* | Total formula weight | 249132.0 |