7KUY
Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, strychnine bound state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0016594 | molecular_function | glycine binding |
A | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0016594 | molecular_function | glycine binding |
B | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0016594 | molecular_function | glycine binding |
C | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0016594 | molecular_function | glycine binding |
D | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0003674 | molecular_function | molecular_function |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0005575 | cellular_component | cellular_component |
E | 0006091 | biological_process | generation of precursor metabolites and energy |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0008218 | biological_process | bioluminescence |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
site_id | PS00236 |
Number of Residues | 15 |
Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC |
Chain | Residue | Details |
A | CYS145-CYS159 | |
E | CYS161-CYS175 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | TYR247-ILE268 | |
D | LYS1-TYR229 | |
D | ARG278-LYS288 | |
D | LYS415-LYS425 | |
A | ARG278-LYS288 | |
A | LYS415-LYS425 | |
B | LYS1-TYR229 | |
B | ARG278-LYS288 | |
B | LYS415-LYS425 | |
C | LYS1-TYR229 | |
C | ARG278-LYS288 | |
C | LYS415-LYS425 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | ASN269-SER273 | |
B | TYR230-ILE251 | |
C | TYR230-ILE251 | |
D | TYR230-ILE251 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | ALA274-LEU294 | |
B | ASN252-ALA256 | |
C | ASN252-ALA256 | |
D | ASN252-ALA256 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | ALA295-LYS305 | |
B | PRO257-SER277 | |
C | PRO257-SER277 | |
D | PRO257-SER277 |
site_id | SWS_FT_FI5 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | ALA306-ALA326 | |
B | ALA289-ALA309 | |
C | ALA289-ALA309 | |
D | ALA289-ALA309 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | TYR454-TYR474 | |
B | ILE394-TYR414 | |
C | ILE394-TYR414 | |
D | ILE394-TYR414 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:O93430 |
Chain | Residue | Details |
E | TYR225 | |
D | GLU199 | |
D | GLU201 | |
D | HIS222 | |
A | GLU201 | |
A | HIS222 | |
B | GLU199 | |
B | GLU201 | |
B | HIS222 | |
C | GLU199 | |
C | GLU201 | |
C | HIS222 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000250|UniProtKB:P23415 |
Chain | Residue | Details |
E | LEU285 | |
B | TYR209 | |
C | TYR209 | |
D | TYR209 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34473954 |
Chain | Residue | Details |
E | ASN32 | |
E | ASN220 | |
C | LEU268 | |
D | LEU268 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132 |
Chain | Residue | Details |
E | TYR333 | |
A | ASN76 | |
B | ASN45 | |
B | ASN76 | |
C | ASN45 | |
C | ASN76 | |
D | ASN45 | |
D | ASN76 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | CROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132 |
Chain | Residue | Details |
E | THR333 | |
E | GLY333 |