7KQL

Anti-Tim3 antibody Fab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Tim3.18 Fab heavy chain	polymer	234	24986.9	1		Homo sapiens
2	L	Tim3.18 Fab light chain	polymer	215	23415.9	1		Homo sapiens
3	T	Hepatitis A virus cellular receptor 2	polymer	129	14465.4	1	UniProt (Q8TDQ0) Pfam (PF07686) In PDB	Homo sapiens (Human)	HAVcr-2,T-cell immunoglobulin and mucin domain-containing protein 3,TIMD-3,T-cell immunoglobulin mucin receptor 3,TIM-3,T-cell membrane protein 3
4	H, L	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
5		water	water		18.0	644	Chemie (HOH)

Sequence modifications

T: -8 - 111 (UniProt: Q8TDQ0)

PDB	External Database	Details
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ala -10	-	expression tag
Ala -9	-	expression tag
Glu -7	Leu 14	conflict
Val -6	Leu 15	conflict
Phe -4	Leu 17	conflict
Gln -3	Leu 18	conflict
Gly -2	Thr 19	conflict
Pro -1	Arg 20	conflict
Gly 0	Ser 21	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	62868.2
Non-Polymers*	Number of molecules	4
	Total formula weight	368.4
All*	Total formula weight	63236.6

*Water molecules are not included.