7KP8
asymmetric mTNF-alpha hTNFR1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tumor necrosis factor | polymer | 147 | 16324.5 | 3 | UniProt (P06804) Pfam (PF00229) | Mus musculus (Mouse) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | D, E (E, F) | Tumor necrosis factor receptor superfamily member 1A | polymer | 142 | 16052.0 | 2 | UniProt (P19438) Pfam (PF00020) | Homo sapiens (Human) | Tumor necrosis factor receptor 1,TNF-R1,Tumor necrosis factor receptor type I,TNFR-I,p55,p60 |
| 3 | F (C) | 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole | non-polymer | 449.5 | 1 | Chemie (A7G) | |||
| 4 | G, H, I (A, B, F) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
E, F: 14 - 155 (UniProt: P19438)
| PDB | External Database | Details |
|---|---|---|
| Asp 25 | Asn 54 | engineered mutation |
| Ser 153 | Cys 182 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 81077.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 449.5 | |
| All* | Total formula weight | 81527.1 |
