7KP8
asymmetric mTNF-alpha hTNFR1 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| A | 0006955 | biological_process | immune response |
| A | 0016020 | cellular_component | membrane |
| B | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| B | 0006955 | biological_process | immune response |
| B | 0016020 | cellular_component | membrane |
| C | 0005164 | molecular_function | tumor necrosis factor receptor binding |
| C | 0006955 | biological_process | immune response |
| C | 0016020 | cellular_component | membrane |
| E | 0005031 | molecular_function | tumor necrosis factor receptor activity |
| E | 0006693 | biological_process | prostaglandin metabolic process |
| E | 0006954 | biological_process | inflammatory response |
| E | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
| F | 0005031 | molecular_function | tumor necrosis factor receptor activity |
| F | 0006693 | biological_process | prostaglandin metabolic process |
| F | 0006954 | biological_process | inflammatory response |
| F | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00251 |
| Number of Residues | 17 |
| Details | THD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPaDGLYLVysQVlF |
| Chain | Residue | Details |
| A | LEU48-PHE64 |
| site_id | PS00652 |
| Number of Residues | 38 |
| Details | TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CpqgkyiHpqdnsi....C..Ctk.Chkgtylynd..Cpgpgq.DTDC |
| Chain | Residue | Details |
| E | CYS15-CYS52 | |
| E | CYS55-CYS96 | |
| E | CYS96-CYS137 |
| site_id | PS01186 |
| Number of Residues | 14 |
| Details | EGF_2 EGF-like domain signature 2. CtChaGFflrene..C |
| Chain | Residue | Details |
| E | CYS137-CYS150 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"TNFR-Cys 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"TNFR-Cys 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 80 |
| Details | Repeat: {"description":"TNFR-Cys 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
