7KLC

Crystal structure of M4H2K1 Fab bound to HIV-1 BG505 gp120 core and to 17b Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	M4H2K1 Fab heavy chain	polymer	226	24216.1	1		Mus musculus (Mouse)
2	B (L)	M4H2K1 Fab light chain	polymer	218	23805.5	1		Mus musculus (Mouse)
3	C (C)	17b Fab light chain	polymer	214	23399.9	1		Homo sapiens (Human)
4	D (D)	17b Fab heavy chain	polymer	229	24411.3	1		Homo sapiens (Human)
5	E (A)	HIV-1 clade A BG505 gp120,HIV-1 clade A BG505 gp120	polymer	383	42305.8	1	UniProt (Q2N0S5) Pfam (PF00516)	Human immunodeficiency virus 1 (HIV-1)
6	F, I, J (B, G, I)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
7	G (E)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
8	H (F)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
9	K, L, M, N, O... (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	7	Chemie (NAG)

Sequence modifications

A: 44 - 191 (UniProt: Q2N0S5)
A: 195 - 492 (UniProt: Q2N0S5)

PDB	External Database	Details
Gly 192	-	linker
Ala 193	-	linker
Gly 194	-	linker
Asn 332	Thr 330	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	138138.7
Branched	Number of molecules	5
	Total formula weight	2770.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1548.5
All*	Total formula weight	142457.8

*Water molecules are not included.