7KJX

Structure of HIV-1 reverse transcriptase initiation complex core with nevirapine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase/ribonuclease H	polymer	562	64705.3	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)	Pr160Gag-Pol
2	B	reverse transcriptase p51 subunit	polymer	442	51585.3	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1 (HIV-1)
3	C	HIV-1 viral RNA fragment	polymer	26	8437.1	1		Human immunodeficiency virus 1
4	D	tRNA lysine 3 fragment with GNRA tetraloop	polymer	22	7030.3	1		Homo sapiens
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A	11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE	non-polymer		266.3	1	Chemie (NVP)

Sequence modifications

A: 1 - 560 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	expression tag
Val 0	-	expression tag
Cys 258	Gln 857	engineered mutation
Ser 280	Cys 879	conflict
Gln 478	Glu 1077	engineered mutation

B: 1 - 440 (UniProt: P03366)

PDB	External Database	Details
Met -1	-	expression tag
Val 0	-	expression tag
Ser 280	Cys 879	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131758.0
Non-Polymers*	Number of molecules	2
	Total formula weight	290.6
All*	Total formula weight	132048.6

*Water molecules are not included.