7KI3
Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Protein argonaute-2 | polymer | 859 | 97402.2 | 2 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) | Homo sapiens (Human) | hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
| 2 | B, E (B, E) | miR-122 | polymer | 23 | 7439.4 | 2 | Homo sapiens | ||
| 3 | C, F (C, F) | HCV genotype 1a miR-122 site-1 | polymer | 29 | 9288.6 | 2 | Hepacivirus C | ||
| 4 | G, H, I (A, C, D) | BARIUM ION | non-polymer | 137.3 | 3 | Chemie (BA) |
Sequence modifications
A, D: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Asp 387 | Ser 387 | engineered mutation |
| Ala 824 | Ser 824 | engineered mutation |
| Asp 828 | Ser 828 | engineered mutation |
| Asp 831 | Ser 831 | engineered mutation |
| Ala 834 | Ser 834 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 228260.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 412.0 | |
| All* | Total formula weight | 228672.4 |
