7KI1

Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	394	45699.4	1	UniProt (P63092) Pfam (PF00503) In PDB	Homo sapiens (Human)	Adenylate cyclase-stimulating G alpha protein
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	340	37413.9	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (Human)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	58	6375.3	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (Human)	G gamma-I
4	N	Nb35	polymer	128	13885.4	1		Homo sapiens (Human)
5	R	Glucagon-like peptide 1 receptor	polymer	491	56748.4	1	UniProt (P43220) Pfam (PF02793) Pfam (PF00002) In PDB	Homo sapiens (Human)	GLP-1R
6	P	Taspoglutide	polymer	31	3342.7	1	Pfam (PF00123) UniProt (by SIFTS) (P01275) In PDB	synthetic construct
7		water	water		18.0	73	Chemie (HOH)

Sequence modifications

A: 1 - 394 (UniProt: P63092)

PDB	External Database	Details
Asn 54	Ser 54	conflict
Ala 226	Gly 226	conflict
Ala 268	Glu 268	conflict
Lys 271	Asn 271	conflict
Asp 274	Lys 274	conflict
Lys 280	Arg 280	conflict
Asp 284	Thr 284	conflict
Thr 285	Ile 285	conflict
Ser 366	Ala 366	conflict

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Gln 1	-	expression tag

R: 24 - 463 (UniProt: P43220)

PDB	External Database	Details
Met -8	-	initiating methionine
Lys -7	-	expression tag
Thr -6	-	expression tag
Ile -5	-	expression tag
Ile -4	-	expression tag
Ala -3	-	expression tag
Leu -2	-	expression tag
Ser -1	-	expression tag
Tyr 0	-	expression tag
Ile 1	-	expression tag
Phe 2	-	expression tag
Cys 3	-	expression tag
Leu 4	-	expression tag
Val 5	-	expression tag
Phe 6	-	expression tag
Ala 7	-	expression tag
Asp 8	-	expression tag
Tyr 9	-	expression tag
Lys 10	-	expression tag
Asp 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Asp 14	-	expression tag
Leu 15	-	expression tag
Glu 16	-	expression tag
Val 17	-	expression tag
Leu 18	-	expression tag
Phe 19	-	expression tag
Gln 20	-	expression tag
Gly 21	-	expression tag
Pro 22	-	expression tag
Ala 23	-	expression tag
Phe 260	Leu 260	conflict
Pro 464	-	expression tag
Ala 465	-	expression tag
Gly 466	-	expression tag
Leu 467	-	expression tag
Glu 468	-	expression tag
Val 469	-	expression tag
Leu 470	-	expression tag
Phe 471	-	expression tag
Gln 472	-	expression tag
Gly 473	-	expression tag
Pro 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag
His 481	-	expression tag
His 482	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	163465.2
All*	Total formula weight	163465.2

*Water molecules are not included.