7KH0
Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Vasopressin V2 receptor | polymer | 389 | 42346.1 | 1 | UniProt (P30518) Pfam (PF00001) In PDB | Homo sapiens (Human) | V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38613.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | A | Guanine nucleotide-binding protein G(i) subunit alpha-3, Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short fusion | polymer | 372 | 43298.1 | 1 | UniProt (P08754) UniProt (P63092-2) Pfam (PF00503) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens (Human) | G(i) alpha-3,Adenylate cyclase-stimulating G alpha protein |
4 | L | Arg-vasopressin | polymer | 10 | 1086.2 | 1 | UniProt (P01185) Pfam (PF00220) In PDB | Homo sapiens (Human) | AVP-NPII |
5 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 67 | 7432.6 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
6 | S | Single Fab chain (scFv16) | polymer | 248 | 26450.5 | 1 | Homo sapiens (Human) | ||
7 | N | Nanobody 35 | polymer | 134 | 14714.3 | 1 | Lama glama (llama) |
Sequence modifications
R: 1 - 371 (UniProt: P30518)
B: 2 - 340 (UniProt: P62873)
A: 9 - 25 (UniProt: P08754)
A: 26 - 394 (UniProt: P63092-2)
L: 1 - 9 (UniProt: P01185)
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Val -1 | - | expression tag |
Asp 0 | - | expression tag |
Ala 372 | - | expression tag |
Ala 373 | - | expression tag |
Ala 374 | - | expression tag |
Leu 375 | - | expression tag |
Glu 376 | - | expression tag |
Val 377 | - | expression tag |
Leu 378 | - | expression tag |
Phe 379 | - | expression tag |
Gln 380 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
A: 26 - 394 (UniProt: P63092-2)
PDB | External Database | Details |
---|---|---|
Asp 188 | Ala 174 | conflict |
PDB | External Database | Details |
---|---|---|
Nh2 10 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 173941.0 | |
All* | Total formula weight | 173941.0 |