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7KH0

Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0003091biological_processrenal water homeostasis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007608biological_processsensory perception of smell
A0010856molecular_functionadenylate cyclase activator activity
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031748molecular_functionD1 dopamine receptor binding
A0032588cellular_componenttrans-Golgi network membrane
A0046872molecular_functionmetal ion binding
A0046907biological_processintracellular transport
A0048589biological_processdevelopmental growth
A0050796biological_processregulation of insulin secretion
A0050890biological_processcognition
A0060348biological_processbone development
A0060789biological_processhair follicle placode formation
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071377biological_processcellular response to glucagon stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
L0005185molecular_functionneurohypophyseal hormone activity
L0005576cellular_componentextracellular region
R0001992biological_processregulation of systemic arterial blood pressure by vasopressin
R0003084biological_processpositive regulation of systemic arterial blood pressure
R0003092biological_processrenal water retention
R0004930molecular_functionG protein-coupled receptor activity
R0005000molecular_functionvasopressin receptor activity
R0005515molecular_functionprotein binding
R0005768cellular_componentendosome
R0005783cellular_componentendoplasmic reticulum
R0005794cellular_componentGolgi apparatus
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0007599biological_processhemostasis
R0008284biological_processpositive regulation of cell population proliferation
R0008285biological_processnegative regulation of cell population proliferation
R0010628biological_processpositive regulation of gene expression
R0016020cellular_componentmembrane
R0021537biological_processtelencephalon development
R0030139cellular_componentendocytic vesicle
R0030669cellular_componentclathrin-coated endocytic vesicle membrane
R0032870biological_processcellular response to hormone stimulus
R0034097biological_processresponse to cytokine
R0035811biological_processnegative regulation of urine volume
R0038023molecular_functionsignaling receptor activity
R0042277molecular_functionpeptide binding
R0045777biological_processpositive regulation of blood pressure
R0045907biological_processpositive regulation of vasoconstriction
R0048471cellular_componentperinuclear region of cytoplasm
R1902533biological_processpositive regulation of intracellular signal transduction
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASSyMILAMTLDRHRaI
ChainResidueDetails
RALA125-ILE141

site_idPS00264
Number of Residues9
DetailsNEUROHYPOPHYS_HORM Neurohypophysial hormones signature. CYFqNCPrG
ChainResidueDetails
LCYS1-GLY9

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2
RTRP99-ARG113
RARG181-TRP200
RALA294-VAL308

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
ASER54
ALYS211
AASN218
ACYS237
ASER306
AARG380

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AASP215

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
AALA366

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
AGLU314

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RGLY201-GLY220

site_idSWS_FT_FI8
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RMET272-TRP293

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RLEU309-PHE328

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:9224808
ChainResidueDetails
RCYS341
RCYS342

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN22

222624

PDB entries from 2024-07-17

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