7KG9

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56W mutant with pyruvate bound in the active site and L-lysine bound at the allosteric site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	4-hydroxy-tetrahydrodipicolinate synthase	polymer	310	34233.3	6	UniProt (Q9PPB4) Pfam (PF00701)	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	HTPA synthase
2	AA, BA, CA, G, GA... (C, A, D, B, F)	1,2-ETHANEDIOL	non-polymer		62.1	17	Chemie (EDO)
3	J, SA, TA (A, F)	TRIETHYLENE GLYCOL	non-polymer		150.2	3	Chemie (PGE)
4	EA, K, LA, U, WA... (C, A, D, B, F)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	6	Chemie (PEG)
5	L, V (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	FA, M, NA, OA, X... (C, A, D, E, B...)	LYSINE	non-polymer		147.2	6	Chemie (LYS)
7	N, Y (A, B)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
8	DA, JA, KA, S, T... (C, D, B, F)	MAGNESIUM ION	non-polymer		24.3	7	Chemie (MG)
9	MA, W (D, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
10	AB, BB, CB, DB, EB... (B, C, D, E, F...)	water	water		18.0	764	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 298 (UniProt: Q9PPB4)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Trp 56	His 56	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	205399.9
Non-Polymers*	Number of molecules	45
	Total formula weight	3886.4
All*	Total formula weight	209286.3

*Water molecules are not included.