7KEZ
Crystal structure of bH1 Fab variant (CDR H3 loop design 16_0325) in complex with VEGF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | anti-VEGF-A Fab bH1 heavy chain | polymer | 239 | 25451.4 | 1 | Homo sapiens | ||
| 2 | B (L) | anti-VEGF-A Fab bH1 light chain | polymer | 218 | 23956.6 | 1 | Homo sapiens | ||
| 3 | C (V) | Isoform L-VEGF206 of Vascular endothelial growth factor A | polymer | 116 | 13548.4 | 1 | UniProt (P15692-14) Pfam (PF00341) UniProt (by SIFTS) (P15692) | Homo sapiens (Human) | VEGF-A,Vascular permeability factor,VPF |
| 4 | D (H) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F, G (H, L, V) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
V: 1 - 110 (UniProt: P15692-14)
| PDB | External Database | Details |
|---|---|---|
| His 111 | - | expression tag |
| His 112 | - | expression tag |
| His 113 | - | expression tag |
| His 114 | - | expression tag |
| His 115 | - | expression tag |
| His 116 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62956.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 62991.9 |
