7KA0

Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and phenylalanine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Phenylalanine--tRNA ligase alpha subunit	polymer	341	37415.3	2	UniProt (P9WFU3) Pfam (PF02912) Pfam (PF01409)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	Phenylalanyl-tRNA synthetase alpha subunit,PheRS
2	B, E (B, E)	Phenylalanine--tRNA ligase beta subunit	polymer	835	88867.2	2	UniProt (P9WFU1) Pfam (PF01588) Pfam (PF03483) Pfam (PF03484) Pfam (PF17759) Pfam (PF03147)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	Phenylalanyl-tRNA synthetase beta subunit,PheRS
3	C, F (C, F)	tRNA(Phe)	polymer	77	24842.8	2	GenBank (1251771558)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
4	BA, G (D, A)	PHENYLALANINE	non-polymer		165.2	2	Chemie (PHE)
5	EA, FA, H, HA, I... (D, A, E, B)	GLYCEROL	non-polymer		92.1	12	Chemie (GOL)
6	GA, J (D, A)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
7	K, QA, X (A, E, B)	TRIETHYLENE GLYCOL	non-polymer		150.2	3	Chemie (PGE)
8	AA, CA, KA, MA, NA... (C, D, E, A, F...)	MAGNESIUM ION	non-polymer		24.3	12	Chemie (MG)
9	DA, LA, OA, Q, S... (D, E, B)	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
10	IA, RA, T (D, E, B)	POTASSIUM ION	non-polymer		39.1	3	Chemie (K)
11	AB, VA, WA, XA, YA... (F, A, B, C, D...)	water	water		18.0	904	Chemie (HOH)

Sequence modifications

B, E: 1 - 831 (UniProt: P9WFU1)

PDB	External Database	Details
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	302250.6
Non-Polymers*	Number of molecules	41
	Total formula weight	3085.5
All*	Total formula weight	305336.1

*Water molecules are not included.