7K7O
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Non-receptor tyrosine-protein kinase TYK2 | polymer | 317 | 35499.2 | 2 | UniProt (P29597) Pfam (PF07714) In PDB | Homo sapiens (Human) | |
2 | A, B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide | non-polymer | 419.4 | 2 | Chemie (VZJ) | |||
3 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B: 575 - 869 (UniProt: P29597)
PDB | External Database | Details |
---|---|---|
Met 553 | - | expression tag |
Gly 554 | - | expression tag |
Ser 555 | - | expression tag |
Ser 556 | - | expression tag |
His 557 | - | expression tag |
His 558 | - | expression tag |
His 559 | - | expression tag |
His 560 | - | expression tag |
His 561 | - | expression tag |
His 562 | - | expression tag |
Ser 563 | - | expression tag |
Ser 564 | - | expression tag |
Gly 565 | - | expression tag |
Glu 566 | - | expression tag |
Thr 567 | - | expression tag |
Val 568 | - | expression tag |
Arg 569 | - | expression tag |
Phe 570 | - | expression tag |
Gln 571 | - | expression tag |
Gly 572 | - | expression tag |
His 573 | - | expression tag |
Met 574 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70998.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 838.9 | |
All* | Total formula weight | 71837.2 |