7K62
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dihydrofolate reductase | polymer | 167 | 18737.0 | 2 | UniProt (A0A1V3XYG5) Pfam (PF00186) UniProt (by SIFTS) (A0A653EQ34) In PDB | Mycobacterium kansasii | |
2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
3 | A, B | 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid | non-polymer | 360.4 | 2 | Chemie (MMV) | |||
4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
5 | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 158 (UniProt: A0A1V3XYG5)
PDB | External Database | Details |
---|---|---|
Met -8 | - | initiating methionine |
Ala -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
Val 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 37474.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2331.8 | |
All* | Total formula weight | 39805.8 |