7K62
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | binding site for residue NAP A 201 |
Chain | Residue |
A | TRP5 |
A | LEU64 |
A | SER65 |
A | ARG66 |
A | GLN67 |
A | GLY79 |
A | ILE94 |
A | GLY95 |
A | GLY96 |
A | GLU97 |
A | GLN98 |
A | ALA6 |
A | ILE99 |
A | TYR100 |
A | LEU102 |
A | ALA126 |
A | MMV202 |
A | HOH315 |
A | HOH317 |
A | HOH327 |
A | HOH340 |
A | HOH349 |
A | ILE13 |
A | GLY17 |
A | ASP18 |
A | GLY42 |
A | ARG43 |
A | ARG44 |
A | THR45 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue MMV A 202 |
Chain | Residue |
A | ILE4 |
A | TRP5 |
A | ALA6 |
A | ILE19 |
A | ASP26 |
A | PHE30 |
A | LYS31 |
A | LEU49 |
A | ARG59 |
A | ILE94 |
A | TYR100 |
A | TYR157 |
A | NAP201 |
A | HOH321 |
A | HOH332 |
site_id | AC3 |
Number of Residues | 2 |
Details | binding site for residue EDO A 203 |
Chain | Residue |
A | TRP21 |
A | VAL23 |
site_id | AC4 |
Number of Residues | 26 |
Details | binding site for residue NAP B 201 |
Chain | Residue |
B | TRP5 |
B | ALA6 |
B | ILE13 |
B | GLY17 |
B | ASP18 |
B | ILE19 |
B | GLY42 |
B | ARG43 |
B | ARG44 |
B | THR45 |
B | LEU64 |
B | SER65 |
B | ARG66 |
B | GLN67 |
B | GLY79 |
B | ILE94 |
B | GLY95 |
B | GLY96 |
B | GLU97 |
B | GLN98 |
B | ILE99 |
B | TYR100 |
B | LEU102 |
B | MMV202 |
B | HOH304 |
B | HOH310 |
site_id | AC5 |
Number of Residues | 14 |
Details | binding site for residue MMV B 202 |
Chain | Residue |
B | ILE4 |
B | TRP5 |
B | ALA6 |
B | ILE19 |
B | ASP26 |
B | PHE30 |
B | LYS31 |
B | LEU49 |
B | ARG59 |
B | ILE94 |
B | TYR100 |
B | TYR157 |
B | NAP201 |
B | HOH307 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue EDO B 203 |
Chain | Residue |
B | TRP21 |
B | VAL23 |
B | HOH309 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWrvpe.DlshFkriT |
Chain | Residue | Details |
A | VAL12-THR34 |