7K3S

Solution NMR Structure of the Coiled-coil BRCA1-PALB2 Heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Breast cancer type 1 susceptibility protein homolog	polymer	60	6935.7	1	UniProt (P48754) In PDB	Mus musculus (Mouse)	RING-type E3 ubiquitin transferase BRCA1
2	B	Partner and localizer of BRCA2	polymer	68	7948.2	1	UniProt (Q3U0P1) In PDB	Mus musculus (Mouse)

Sequence modifications

A: 2 - 53 (UniProt: P48754)

PDB	External Database	Details
Met 1	-	initiating methionine
Glu 54	-	expression tag
His 55	-	expression tag
His 56	-	expression tag
His 57	-	expression tag
His 58	-	expression tag
His 59	-	expression tag
His 60	-	expression tag

B: 101 - 160 (UniProt: Q3U0P1)

PDB	External Database	Details
Leu 161	-	expression tag
Glu 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	14883.9
All*	Total formula weight	14883.9

*Water molecules are not included.