7K0U
Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcription initiation factor TFIID subunit 1 | polymer | 137 | 15882.8 | 2 | UniProt (P21675) Pfam (PF00439) | Homo sapiens (Human) | Cell cycle gene 1 protein,TBP-associated factor 250 kDa,p250,Transcription initiation factor TFIID 250 kDa subunit,TAFII250 |
| 2 | C, D, E, F (A, B) | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | non-polymer | 521.7 | 4 | Chemie (R78) | |||
| 3 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 1501 - 1635 (UniProt: P21675)
| PDB | External Database | Details |
|---|---|---|
| Ser 1499 | - | expression tag |
| Met 1500 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31765.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2086.6 | |
| All* | Total formula weight | 33852.2 |
