7K0U
Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0005669 | cellular_component | transcription factor TFIID complex |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0016251 | molecular_function | RNA polymerase II general transcription initiation factor activity |
| A | 0017025 | molecular_function | TBP-class protein binding |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0005669 | cellular_component | transcription factor TFIID complex |
| B | 0006366 | biological_process | transcription by RNA polymerase II |
| B | 0016251 | molecular_function | RNA polymerase II general transcription initiation factor activity |
| B | 0017025 | molecular_function | TBP-class protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue R78 A 1701 |
| Chain | Residue |
| A | TRP1526 |
| B | R781701 |
| B | R781703 |
| A | PRO1527 |
| A | VAL1532 |
| A | TYR1582 |
| A | ASN1583 |
| A | TYR1589 |
| A | HOH1801 |
| B | PHE1509 |
| B | ARG1554 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue R78 B 1701 |
| Chain | Residue |
| A | PHE1509 |
| A | ASN1533 |
| A | PHE1536 |
| A | VAL1537 |
| A | R781701 |
| B | ARG1554 |
| B | LYS1555 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue R78 B 1702 |
| Chain | Residue |
| A | PHE1509 |
| A | ARG1554 |
| B | PRO1527 |
| B | TYR1582 |
| B | ASN1583 |
| B | TYR1589 |
| B | R781703 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue R78 B 1703 |
| Chain | Residue |
| A | ARG1554 |
| A | LYS1555 |
| A | R781701 |
| B | PHE1509 |
| B | ASN1533 |
| B | PHE1536 |
| B | VAL1537 |
| B | R781702 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SwpFhhpvNkkfvp..DYYkvIvnpMdletIrkniskhk..Yqsresflddvnl.IlaNSvkY |
| Chain | Residue | Details |
| A | SER1525-TYR1582 |
